The bulk of the urine-recovered dye must have been taken up into the attractive layer of the skin and then slowly released into the circulation. A cumulative 4-day absorption assuming cm 2 of scalp was given as zero.
According to the results obtained, Daphnia magna is probably the most delicate organism, and resorcinol could be classified as acutely toxic solely to Daphnia. However, this value is questionable for use as a restrict worth in threat evaluation that is the very best focus examined in this study , and the NOEC could be considerably larger than acknowledged in the study. In the atmosphere, resorcinol is quickly degraded half-life about 2 h by reaction with photochemically produced hydroxyl radicals. Under aerobic conditions, resorcinol proved to be readily biodegradable in a test carried out based on OECD TG C, and it is prone to be biodegraded under anaerobic circumstances.
No resorcinol-associated macroscopic findings, organ weight, or antagonistic microscopic goal organ effects have been noticed within the F 0 and F 1 parental animals. The F zero and F 1 females continued to receive the resorcinol all through mating, gestation, and lactation and through the day of euthanasia for examine design, see Appendix 7. There have been no F 0 and F 1 parental resorcinol-related deaths or clinical findings through the weekly detailed bodily examinations. In controls and the high-dose group, a qualitative histopathological evaluation of the brain forebrain, midbrain, and hindbrain was additionally carried out for the aforementioned animals RTF, There had been no opposed results regarding reproductive efficiency, mortality, and body or organ weights.
Animals that died confirmed hyperaemia and distension of stomach and intestine, while there were no gross lesions at necropsy in survivors Flickinger, In another research with CFY rats. Most of the studies are of adequate high quality and acceptable for danger characterization purposes.
British Journal of Industrial Medicine , Toxicologic Pathology , Toxicology and Applied Pharmacology , Arnott DG, Doniach I The effect of compounds allied to resorcinol upon the uptake of radioactive iodine I by the thyroid of the rat. IARC evaluated the carcinogenicity of resorcinol in and concluded that there are no epidemiological information related to the carcinogenicity of resorcinol in humans and that the proof of its carcinogenicity in animals is inadequate; thus, resorcinol is not classifiable as to its carcinogenicity to people. JECFA assessed the hazards from using resorcinol as a food flavouring agent and concluded that this use is of no safety concern. Overall, the studies aren't adequate for a statistical extrapolation approach in accordance with the EU Technical Guidance Document EC, a.
- The third examine, carried out in , included of energetic workers.
- Assuming a body weight of 64 kg IPCS, provides an publicity estimate of zero.
- Most of the research are of enough quality and acceptable for danger characterization purposes.
- One issue growing potential poisonous results is the application of resorcinol to injured pores and skin Cassano et al.
- Two lengthy-time period studies with Swiss mice or NZW rabbits, where the animals were treated with zero.
- British Journal of Industrial Medicine , Toxicologic Pathology , Toxicology and Applied Pharmacology , Arnott DG, Doniach I The impact of compounds allied to resorcinol upon the uptake of radioactive iodine I by the thyroid of the rat.
- The weight of evidence means that rodents are more delicate to thyroid effects than people.
In in vitro human pores and skin studies, resorcinol was evaluated from a representative hair dye formulation that contained 0. However, it ought to be thought-about that acned pores and skin may be damaged due either to scratching or to the blemishes themselves.
There are differences in thyroid physiology between people and animals. The weight of evidence suggests that rodents are extra sensitive to thyroid effects than humans.
In both species, there have been no antagonistic results on final mean body weights, haematology, or clinical chemistry parameters, and no chemical-related gross or microscopic lesions have been observed. In one other examine, rats have been uncovered to zero or zero. No thyroid hormone measurements had been performed.
The microscopic examination of the thyroid gave minimal adjustments follicular hyperplasia , which have been statistically not important between controls and individual dose teams RTF, In vitro studies have been carried out to assess the consequences of resorcinol on thyroid operate. In https://www.pinterest.com/kastruppovlsen/ -dose groups, a decrease in physique weight and decreased survival had been noted. Owing to concern concerning the thyroid effects of resorcinol, which have been shown in human studies to happen at excessive doses, this finish-level in particular has been the point of focus in several studies. In many of the older research, the results of resorcinol exposure on the thyroid gland are conflicting. It has been advised that thyroid results seem to be dependent on an administration route that allows for continued systemic publicity e.
There have been no revealed animal research showing thyroidal effects with a dose—response relationship that could possibly be used for a tolerable consumption. In the frame of a full life cycle toxicity take a look at OECD TG , Lima noticed no antagonistic results after 48 h of exposure at the highest concentration tested, 0. Furthermore, Cronin et al. The fish and pond snails were placed directly into the aquaria, whereas the remaining five species have been segregated in different baskets and suspended in the aquaria. The only investigation into this end-point is that from the dose vary-discovering research reported in sections eight.
One issue growing potential poisonous effects is the applying of resorcinol to injured skin Cassano et al. Surviving F 0 parental and F 1 following selection rats underwent full gross necropsy following the breeding period seven F zero males per group , following completion of weaning of F 1 pups F zero females , following scheduled necropsy of F zero females remaining seven F 0 males per group , on PND 28 F 1 uncovered pups , or on PND 30 or 70 F 1 pups chosen for behavioural testing.
The acute dermal toxicity of resorcinol was studied in male albino rabbits Koppers Company, Signs of intoxication included salivation, tremors, and convulsions, and handled skin areas showed slight erythema and excessive dryness. Mean information for 3 donors and sixteen replicates indicate a plateau in receptor fluid concentration between 24 and 48 h, as reflected by cumulative absorption values of 1. A regular-state permeability coefficient. For male albino rats pressure not given;.