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British Journal of Industrial Medicine , Toxicologic Pathology , Toxicology and Applied Pharmacology , Arnott DG, Doniach I The impact of compounds allied to resorcinol upon the uptake of radioactive iodine I by the thyroid of the rat. IARC evaluated the carcinogenicity of resorcinol in and concluded that there aren't any epidemiological information related to the carcinogenicity of resorcinol in humans and that the evidence of its carcinogenicity in animals is insufficient; thus, resorcinol isn't classifiable as to its carcinogenicity to people. JECFA assessed the hazards from the use of resorcinol as a meals flavouring agent and concluded that this use is of no safety concern. Overall, the research aren't enough for a statistical extrapolation method based on the EU Technical Guidance Document EC, a.

No resorcinol-associated macroscopic findings, organ weight, or antagonistic microscopic target organ results were noticed within the F 0 and F 1 parental animals. The F 0 and F 1 females continued to receive the resorcinol throughout mating, gestation, and lactation and through the day of euthanasia for research design, see Appendix 7. There were no F 0 and F 1 parental resorcinol-associated deaths or scientific findings in the course of the weekly detailed physical examinations. In controls and the high-dose group, a qualitative histopathological evaluation of the mind forebrain, midbrain, and hindbrain was also performed for the aforementioned animals RTF, There had been no antagonistic results concerning reproductive performance, mortality, and body or organ weights.

The organisms have been exposed to the take a look at concentrations for 96 h. Biological observations had been carried out daily.
The tolerable consumption of zero. It is due to this fact attainable that these neurological results are as a result of acute effect of the gavage administration. CNS effects in people and animals have been related to acute exposure to resorcinol.
Fifty per cent of survivors have been sacrificed 1 week later, and blood and urine samples had been taken. Resorcinol confirmed a focus-dependent improve in labelling index [ three H]thymidine , acanthosis, and papillomatosis. After utility of an ointment containing To examine the goitrogenic exercise of resorcinol, female Wistar rats had been handled twice daily for 28 days by rubbing 6 g of an ointment containing Increased thyroid gland weights 2.
In practice, nonetheless, the incidence of sensitization seems to be low. In animal research, the toxicological effects reported to be brought on by administration of resorcinol include thyroid dysfunction, irritation to pores and skin and eyes, CNS results, and altered adrenal gland relative weights. After topical use of excessive concentrations of resorcinol, CNS disturbances, corresponding to dizziness, vertigo, confusion, disorientation, amnesia, or tremors, or pink blood cell adjustments, such as methaemoglobinaemia, haemolytic anaemia, haemoglubinuria, or cyanosis, have been reported. One issue increasing potential poisonous results is the application of resorcinol to injured pores and skin.

Other skin results had been hyperplasia, hyperkeratosis, inflammation, and sebaceous gland hyperplasia, whereas there were no systemic remedy-related lesions. With resorcinol, a number of initiation—promotion studies with hamsters Maruyama et al. Female Syrian golden hamsters 10—20 per group were treated with two subcutaneous injections of. In a research carried out by Hasegawa et al.
Although thyroid results are a significant finish-level in each human case-research and animal research, there is a lack of consistency within the results in the animal research. Resorcinol caused no antagonistic results in a number of reproduction and developmental toxicity research in rats and rabbits. Resorcinol is not considered to be genotoxic.
In another study, male F rats had been handled with three intraperitoneal injections of three-methyl-. Based on the research of Yeung et al.


For the benthic and terrestrial compartments, the obtainable toxicity data can't be thought to be enough for a quantitative danger characterization. However, these compartments are less related for resorcinol, due to marginal releases and emissions to those compartments as well as a really low potential for adsorption of resorcinol to natural matter.
According to the outcomes obtained, Daphnia magna is the most delicate organism, and resorcinol may be categorised as acutely poisonous only to Daphnia. However, this worth is questionable for use as a restrict worth in risk assessment that is the highest concentration tested in this study , and the NOEC could be considerably greater than acknowledged in the research. In the environment, resorcinol is rapidly degraded half-life about 2 h by reaction with photochemically produced hydroxyl radicals. Under aerobic situations, resorcinol proved to be readily biodegradable in a test carried out based on OECD TG C, and it is likely to be biodegraded underneath anaerobic situations.
Different research carried out with rats and mice gave no improve in the micronucleus formation in bone marrow cells. Bone marrow smears have been ready at 30 h, and polychromatic erythrocytes per animal were scored Gocke et al. An interim sacrifice at 15 months gave no distinction in haematology, clinical chemistry, or other clinical pathology parameters and no increased incidence of neoplasms or non-neoplastic lesions. Also, at final sacrifice, there was no proof of carcinogenic exercise in males or females of each species.
There are variations in thyroid physiology between people and animals. The weight of proof means that rodents are more sensitive to thyroid results than humans.
The acute dermal toxicity of resorcinol was studied in male albino rabbits Koppers Company, Signs of intoxication included salivation, tremors, and convulsions, and handled skin areas showed slight erythema and extreme dryness. Mean data for three donors and sixteen replicates point out a plateau in receptor fluid concentration between 24 and 48 h, as reflected by cumulative absorption values of 1. A steady-state permeability coefficient. For male albino rats strain not given;.
The elimination was biphasic, with half-lives of 18—21 min and 8. The 14 C exercise was quickly distributed in main tissues such as muscles, kidneys, and liver, without indication of bioaccumulation Merker et al. Any new information being provided in the middle of the OECD evaluation shall be offered to the IPCS in order that an addendum can be prepared for consideration.